Can I run my purifier with only one of the filters?

Your machine has been designed to accommodate both Fellowes® True HEPA Filter with AeraSafe™ Antimicrobial Treatment and Fellowes® Carbon Filter. Using the machine with only one of those filters would dramatically reduce the efficiency of your air purifier and may result in abnormal air circulation noises, as the space left by the missing filter would allow part of your indoor air to circulate freely without being filtered.